The hepatic mitotic activity was observed in two groups of white rats after performing Partial sp´enectomy on one group and splenic autotransplantation on the other group.
Observation on hepatic mitotic activity was also done after injecting serum of each group into the peritoneal cavity of either adult or young white rats.
The following results were obtained
1) The hepatic mitotic activity in the partially splenectomized group showed reduction in 24 to 48 hours, reaching it´s lowest level in 72 hours after operation and returning to it´s normal level ~- in a week.
2) The hepatic mitotic activity in the auto-transplanted group showed reduction in 24 to -48 hours, with a gradual return. to a normal level in a week or more.
3) The hepatic mitotic activity in normal male adult and young white rats to which serum of the partially splenectomized group was injected intraperitoneally, showed reduction in 12 hours, reaching it´s lowest level in 72 hours after in-jection, and a graduall return to normal level in a week.
4) The hepatic mitotic activity in normal male rats, to which serum of the splenic autotransplanted group was injected intraperitoneally; began to decrease in 12 to 48 hours, returning to a normal level gradually in from 72 hours to a week.
5) The splenic remnant of partially splenectomized rats showed compensatory hypertrophy, which was the outcome of immature reticulum -cell proliferation followed by the for-mation of white and red pulp and splenc sinuses, etc.
6) The splenic grafts of auto-transplanted rats became necrotic, and then, regenerated by the similar processes in the splenic remnants of partially splenectomized rats.
These results suggest that both the serum of the partially splenec tomizecd and splenic autotransplanted ? rats contains especially abundant hepatic mitosis-inhibiting factors.
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